GLISOPRENINS, NEW INHIBITORS OF ACYL-CoA: CHOLESTEROL ACYLTRANSFERASE PRODUCED BY Gliocladium sp. FO-1513 I. PRODUCTION, ISOLATION AND PHYSICO-CHEMICAL AND BIOLOGICAL PROPERTIES HlROSHI TOMODA, XlN-Hui HUANG, HlROYUKI NlSHIDAf, ROKURO MASUMA,
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چکیده
Gliocladium sp. FO-1513 was found to produce novel inhibitors of acyl-CoA: cholesterol acyltransferase (ACAT). Twoactive compounds, designated glisoprenins A and B, were isolated from the culture broth of the producing strain by a conventional method. The IC50 values of glisoprenins A and B for ACATactivity were 46 and 61fiM in an enzyme assay using rat liver microsomes, and 1.2 and 0.57 /^M in a J774 macrophage assay, respectively.
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تاریخ انتشار 2006